岗位简介

Job Description:

您将从事合成类生物大分子（如寡核苷酸，ADC药物，多肽类药物等）的分离纯化工作；通过分析仪器设备进行定量与定性检测，完成分析方法开发，制备纯化等工作；有机会接触到现有的先进的技术平台，引领药物发现新趋势；有机会和跨国药企药化专家面对面交流学习。

You will be

engaged in the purification of synthetic biomolecules such as oligonucleotides,ADCs, peptide and so on; mainly focusing on purification method development,purification by advanced instruments, quantitative and qualitative analysis.This role provides an opportunity to work with advanced technology platforms and lead the pharmaceutical discovery trends. You will also have the chance to engage in face-to-face exchanges with pharmaceutical experts from multinational companies.

工作职责

Job Responsibilities:

负责合成类生物大分子样品分析与纯化方法开发，制定合理、高效的纯化方案。

纯化制备生物大分子，对纯化后的生物大分子进行质量检测和分析。

拓展完善现有技术平台与方法，提高团队技术实力。

管理项目进程，沟通汇报，和其他部门密切合作，确保按时完成。

参与实验室日常运维和管理，包括工作分配、仪器设备维护及起草设备SOP等。

总结与完善实验室操作规程，不断提高效率与规范程度。

Responsible for sample analysis and purification method development for synthetic biomolecules, develop reasonable

and efficient purification scheme.

Complete the purification process and analyze the quality for the purified sample.

Expand and improve existing platform technologies and methods through learning and thinking. Improve the technical strength of the team.

Manage project progress, communicate and cooperate, report to ensure completion on time.

Participate in the daily operation, maintenance and management of the laboratory, including purchasing routine reagents, maintaining instruments and equipment and drafting equipment SOPs etc.

Optimize laboratory operating procedures to continuously improve efficiency and standardization.

任职要求

Job Requirements

生物化学、生物工程、生物技术、生药学、天然产物化学等相关专业博士学历，CET-6。具备良好的生物化学和纯化基础；

在生物制药领域，具备系统的专业知识和经验，尤其是纯化和分析方面；

熟悉色谱纯化技术原理、技术手段与方法开发思路，包括且不限于SEC、HIC、IEC、RP、AC、超滤、电泳、介质填料等；有抗体偶联药物(antibody-drug conjugate ADC)、寡核苷酸(Oligonucleotide)、多肽化学合成(Peptide)、蛋白类等生物大分子药物相关研究或工作经验优先；

熟悉各种生物分子分析检测手段，包括且不限于LC-MS/TOF/Q-TOF， SDS-PAGE等；

具有积极的学习态度与严谨的科研精神。

有自学的手段与自行设计实验路线的能力，能够独立开展项目。

具备项目管理素养，责任心强，有团队合作、创新、保密意识及职业素养。

具有良好的表达能力，良好的英语听说读写能力

有进取心、能承担挑战、善于调节压力，正直吃苦耐劳、执行力强。

Major in biochemistry, bioengineering,biotechnology or pharmacognosy, natural product chemistry with a doctoral

degree and CET-6, with a strong foundation in biochemistry and purification sciences.

Have a systematic expertise and experience in the biopharmaceutical field, especially for purification and analysis.

Be familiar with the principle of chromatography purification technology, technic and method development strategies, including but not limit to SEC, HIC, IEC, RP, AC, ultrafiltration,electrophoresis, separation media etc; have purification experience in biological macromolecules such as antibody-drug conjugate (ADC),Oligonucleotide, Peptide is preferred.

Be familiar with biomolecular analysis and detection methods, including but not limit to LC-MS/TOF/Q-TOF，SDS-PAGE etc.

Have a positive learning attitude and rigorous scientific spirit.

Can research and design experiment protocols by yourself.

Good project management ability, strong sense of responsibility, teamwork, innovation, confidentiality awareness and

professional qualities.

Exhibit excellent communication skills and good English skills.

Be enterprising, able to take on challenges,be good at adjusting pressure, be honest, hardworking, and have strong

execution ability.